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LEARN MORE ABOUT PRF:
PRF (Platelet-Rich Fibrin): The Ultimate Blood Concentrate
The use of blood concentrates is becoming more and more popular in medical aesthetics to help men and women achieve a younger and fresher look by using their own cells. PRF is the next step in the evolution of natural skin and hair rejuvenation.
What Is PRF?
PRF, or platelet-rich fibrin, is the next generation treatment of platelet concentrate. PRF is a fibrin matrix comprised of platelet cytokines, growth factors and cells used to help promote skin rejuvenation, hair growth and wound healing.
How Is PRF Obtained?
First, blood is drawn into tubes.
The tubes are then centrifuged for 4-5 minutes.
The tubes are taken out of the centrifuge and the top portions of the centrifuged tubes are drawn up to obtain the PRF for clinical treatment.
How Is PRF Different from Traditional Platelet Rich Plasma (PRP)?
The blood that is collected for PRF is spun in a special low-speed centrifuge to isolate the platelets and white blood cells from the red blood cells. In order to obtain PRP, on the other hand, it is necessary to spin the tubes at up to 6x the G-Force of the PRF process. The reason the centrifuge is spun at much higher rate to obtain the PRP is to eliminate all Red Blood Cells (RBC) by pushing them down with gravitational force. This is a good idea; however, by spinning the tube too fast for too long will also eliminate the good cells that we DO want.
The tubes are devoid of any anticoagulant or additives. As a result, fibrinogen molecules can be converted to thrombin into fibrin during the blood clot formation.
Because there is no anticoagulant in the tube that the blood is collected, the plasma forms a platelet and white blood cell-rich fibrin scaffold once injected into the treatment area. The fibrin clot allows for a much slower and longer release of the growth factors and cytokines (up to 1 week versus few hours with PRP), again resulting in more clinical results.
Because the blood is spinning at very low G-force to obtain the PRF, the platelet recovery is close to 100% with the PRF. We are also using only 1/10th of the volume collected. Hence, PRF contain more platelets per mcL than PRP. Additionally, PRF also has leukocytes (WBC) & mesenchymal stem cells, unlike PRP, resulting in more potential clinical results.
How Does PRF Work?
Fibrin is a biological scaffold that forms in response to an injury anywhere in the body. Platelets circulating in the blood will bind to a scaffold of fibrin. When platelets bind to the fibrin scaffold, they become activated and release growth factors, which start the wound healing process by creating new skin cells, collagen and blood vessels. By injecting PRF into an area on the face or scalp, a controlled inflammatory response is created, which kick starts new cell growth and collagen production.
How Is PRF Used?
PRF is used to address many of the same issues as PRP, but PRF releases growth factors for much longer, up to one week, versus PRP which releases growth factors for few hours. This means that PRF could have better longer-term benefits. The growth factors are what stimulate the stem cells to improve collagen and elastin in the skin. The platelets in PRF are thought to be more robust than those in PRP, and to therefore promote faster healing.
The prepared PRF is immediately ready for injection into the face to fill facial folds and wrinkles, to plump the hollows under the eyes and dark circles, and to improve skin tone and texture. The PRF can also be injected into the scalp to aid with hair restoration and growth.
How Does PRF Treat the Under Eye Loose Skin and Dark Circles?
The skin under the eyes is one of the thinnest skin on our body. It can be one of the first areas that show signs of aging. PRF is one of the ideal treatments that improves this area and can be a better option than heat-based skin tightening devices.
PRF can also enhance the results of fillers under the eyes. Injecting fillers under the eyes, like Restylane, can instantly improve the hollowness under the eyes and is a fabulous treatment to instantly rejuvenate this area. However, too much fillers under the eyes can make the eyes look puffy or cause a bluish tinge if injected too superficially. Also, it can be very difficult to treat the dark circles only with fillers. Injecting PRF in additional to the fillers can significantly enhance the results of the fillers by tightening the loose skin under the eyes and improving the dark circles
What are the Benefits of PRF Treatments?
Increases skin elasticity
Smoothing of fine lines and wrinkles
Filling of deeper wrinkles such as nasolabial folds
Filler for under eye to decrease fine lines, hollowness and wrinkles
Tightens and rejuvenates skin
Long-lasting benefits
Fast recovery and no downtime is required
Can be effective on all skin types and colors
Treatment for the early stages of hair loss. The growth factors, white blood cells and the platelets can assist dormant hair follicles to wake up!
Who is an Ideal Candidate to Receive PRP/PRF?
A dull appearance to your skin
Dark under eye circles, hollowness and fine lines
Individuals who have tried dermal filler under the eye and want to try something else
Fine lines and wrinkles
Thinning hair
Loss of skin volume or elasticity
For individuals who want visible results and would prefer something that is naturally derived from their body and love the idea of healing from the inside out.
How Long Does PRF Last?
PRF facial rejuvenation causes your own body to use its own regenerative cascade and what it makes is yours to keep. Unlike Dermal Fillers that dissolve over time, the collagen and plump that PRF brings stays if you take care of your skin and can last a lifetime. PRF treatments generally require 2 treatments 6 weeks apart and yearly for maintenance.
How To Prepare for PRF Treatment?
It is recommended that you drink lots of water before your treatment so that we can easily draw a good amount of blood. We also recommend that you avoid taking any blood thinning medication such as Advil, Aspirin and Ibuprofen. We always recommend discussing the discontinuation of any medication with your medical practitioner. Avoid drinking alcohol just to minimize any unnecessary bruising for 3-5 days. Arnica tablets can be helpful to take 3-5 days before and after your treatment. Expect some bruising and swelling for 3-5 days.
Who is Not an Ideal Candidate? What are Other Considerations and Risks?
Recent neurotoxin or dermal filler, we ask individuals to wait at least two weeks.
History of cervico-facial or blood cancers that are not in full remission
If you are pregnant or nursing
Presence of an acute or systemic infection
Inform us if you suffer from any blood or autoimmune disorder.
Taking medications that can alter platelet function
Since PRF consists of the individual's blood components, very few side effects are expected. The most common adverse reactions are temporary redness, swelling and bruising at the injection site. In theory vascular occlusions are possible if a large amount of fibrin matrix was directed directly into the blood vessel. There have been no reported cases of this.
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